Abstract
Symptoms occurring from overaction of insulin in the treatment of diabetes usually disappear so quickly and so completely that they are now regarded with little concern. Even coma and convulsions no longer cause alarm. In fact, the production of convulsions in insulin therapy of mental disease is undertaken deliberately in the hope of securing beneficial effects. Yet it should not be forgotten that hypoglycemia may cause death or permanent disability from damage to the brain. A number of reports have been published concerning such results in cases of spontaneous hyperinsulinism as well as in mental and diabetic cases in which insulin therapy has been given. 1 At the same time it must be pointed out that evidence of permanent harm to the central nervous system has been encountered with relative rarity, considering the large number of diabetic patients treated daily with insulin. Textbooks on diabetes cite isolated examples. Joslin and
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