Abstract
Objective The aim of the study was to measure changes in blood flow velocity ( V mean) and erythrocyte deformability (ED) in heavy alcohol drinkers after withdrawal and the relationship between them. Methods The subjects were 32 heavy alcohol drinkers, mean age 47 years (22 men and 10 women). V mean was determined by a transcranial 2 MHz pulsed Doppler probe. ED was estimated by the method of cation-osmotic haemolysis (COH). The results were compared with those for 20 healthy volunteers. Results The study revealed a significant decrease in V mean and ED after admission. V mean in the left middle cerebral artery (MCA) was 45.1 ± 10.2 cm/s as compared with 59.1 ± 7.5 cm/s in controls; in the right MCA, it was 46.8 ± 11.3 cm/s as compared with 59.0 ± 7.6 cm/s in controls ( p < 0.001 in each case). But while V mean was significantly increased after 14 days withdrawal (54.4 ± 10.4 cm/s in the left MCA, p < 0.001, and 54.3 ± 12.1 cm/s in the right MCA, p < 0.01), ED showed only small change. A significant difference between V mean in men and women was found. Conclusion The changes in V mean after withdrawal are more influenced by plasma composition than by changes in ED.
Published Version
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