Abstract
The regulation of cerebral blood flow (CBF) allows for the metabolic demands of the brain to be met and for normal brain function including cognition (learning and memory). Regulation of CBF ensures relatively constant blood flow to the brain despite changes in systemic blood pressure, protecting the fragile micro-vessels from damage. CBF regulation is altered in pregnancy and is further altered by hypertension and hypertensive disorders of pregnancy including preeclampsia. The mechanisms contributing to changes in CBF in normal pregnancy, hypertension, and preeclampsia have not been fully elucidated. This review summarizes what is known about changes in CBF regulation during pregnancy, hypertension, and preeclampsia.
Highlights
Introduction to Cerebral BloodFlow (CBF) RegulationCerebral blood flow (CBF) describes the supply of blood to the brain at any moment in time
24 hours postpartum, cerebral blood flow (CBF) velocity increased in the middle cerebral artery (MCA) a day after delivery, but this increase was not significant when compared to the non-pregnant control group [27]
CBF autoregulation differs the among the different hypertensive disorders of Comparedwomen to normal pregnant womenwomen (CTRL), with pregnant women with chronic normal pregnant (CTRL), pregnant chronic hypertension (CHTN), (CHTN), preeclampsia (PE) or (SiPE)
Summary
Several conditions have been associated with altered CBF autoregulation, including aging, pregnancy, hypertension, and hypertensive disorders of pregnancy. According to a population study investigating CBF in healthy young and healthy elderly patients, CBF is reduced with age, which may be due in part to a reduction in brain volume [10]. The forthcoming sections will discuss evidence for changes that occur in response to hypertension, pregnancy, and hypertensive disorders of pregnancy
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