Abstract
AbstractGlobal and regional cerebral blood flow (CBF) were evaluated with single photon emission computerized tomography (SPECT) utilizing both 133Xenon (133Xe) (47 subjects, 47–82 years old) and 99Tc‐hexamethylpropyleneamine oxime (99Tc‐HMPAO) (27 subjects, 47–80 years old). The 133Xe results showed: among total subjects, no age‐related decline in global CBF, but a significant regional decline in the occipital lobe (p < 0.05); among men, significant age‐related declines in global, frontal, temporal, occipital and right hemisphere CBF (all p < 0.05); among women, no age‐related decline in global or regional CBF. The 99Tc‐HMPAO results showed no age‐related decline in either global or regional perfusion among total subjects, men or women. These results suggest that age‐related global and regional (including frontal lobe) CBF declines do not occur in healthy control subjects after the age of 45 years. However, gender differences in age‐related CBF changes warrant further study.
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