Abstract
Part 1 The anatomic bases: general and comparative anatomy of the cerebral circulation the blood vessel wall - endothelial and smooth muscle cells perivascular nerve fibres in brain vessels functional circuitry. Part 2 The physiological bases: vascular smooth muscle reactivity in vitro and in situ the blood-brain barrier - permeability and substrate transport energy generation in the central nervous system neurotransmitters - metabolic and vascular effects in vivo. Part 3 The pharmacological bases: adrenergic mechanisms dopamine 5-hydroxytryptamine acetylcholine histamine adenosine prostaglandins and other elcosanoids calcium antagonists anaesthetic agents neuropeptides aminobutyric acid (GABA) glutamic acid. Part 4 Fundamental responses of the cerebral circulation: aspects on methods used in vivo changes in arterial gas tensions autoregulation - arterial and intracranial pressure functional depression and stimulation. Part 5 Disordered control - pathophysiological aspects: disturbed cerebral autoregulation disordered substrate supply cerebral ischemia migraine and cluster headache subarachnoid haemorrhage the aged brain.
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