Abstract
Objective The aim of this study was to explore cerebral blood flow (CBF) alterations in subjects with high myopia (HM) using three-dimensional pseudocontinuous arterial spin labeling (3D-pcASL). Methods A total of sixteen patients with bilateral HM and sixteen age- and sex-matched healthy controls (HCs) were recruited. All subjects were right-handed. Image data preprocessing was performed using SPM8 and the DPABI toolbox. Clinical parameters were acquired in the HM group. Two-sample t-tests and Pearson correlation analysis were applied in this study. Results Compared to HCs, patients with HM exhibited significantly increased CBF in the bilateral cerebellum, and no decreases in CBF were detected in the brain. However, no relationship was found between the mean CBF values in the different brain areas and the disease duration (P > 0.05). Conclusions Using ASL analysis, we detected aberrant blood perfusion in the cerebellum in HM patients, contributing to a better understanding of brain abnormalities and brain plasticity through a different perspective.
Highlights
High myopia (HM) is a serious public health issue; this condition is increasingly prevalent among 2.9% of the global population and has affected 10-20% of young adults in East and Southeast Asia [1, 2]
There were no significant differences in age or gender between the HM and healthy controls (HCs) groups (P = 0:818, P = 1)
In the voxel-based analysis, the cerebral blood flow (CBF) differences between the HM patients and the matched healthy subjects are shown in Figure 2 and Table 2
Summary
High myopia (HM) is a serious public health issue; this condition is increasingly prevalent among 2.9% of the global population and has affected 10-20% of young adults in East and Southeast Asia [1, 2]. High myopia (HM) is termed “pathological myopia” or “degenerative myopia” and shows a widespread trend toward the development of pathological and degenerative changes in the neurosensory retina, retinal pigment epithelium (RPE), sclera, and choroid and notably, progression to visual impairment [5, 6]. This condition has an elevated rate of ocular complications in the macula, peripheral retina, and optic nerve, and an increase in intraocular pressure (IOP) often accompanies it [7, 8]. Due to the long history of hypopsia and high incidence of fundus lesions in HM, it is necessary and meaningful to explore metabolism and functional abnormalities in the brain in HM
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