CEREBRAL ATROPHY IN OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT WITH OR WITHOUT DEPRESSIVE SYMPTOMS AND IN PATIENTS WITH LATE-LIFE DEPRESSION

Abstract

total of 15 rats with a mean age of 16.6 months were used for this study. Hippocampus volumes were computed using structural Magnetic ResonanceImaging (MRI). The images [18F]FDG were acquired using PET at baseline and follow-up. Then the percent change of FDG values were calculated with respect to the baseline values. Whole brain images were obtained by MRI using Fast Imaging with Steady State Precession. PET images were then correlated at a voxel level with the hippocampus volume from the MRI images. Results: In WT, average volumes in total brain and hippocampus (mm3) at baseline were 2418.91 6 142.68 and 78.76 6 5.98, respectively. In TG, average volume in total brain and hippocampus were 2390.31 6 210.00 and 81.686 8.28, respectively. In WT, average follow-up total brain volume and hippocampus were 2454.45 6 131.99 and 76.9875 6 2.67, respectively; and 2392.13 6 208.64 and 75.48 6 8.75, respectively in TG. Changes in FDG and hippocampal volume in WT were -0.72 6 6.7% and 5.3 6 5.0%, respectively and in TG were 6.1 6 11% and 6.2 6 3.4%, respectively. In WT, 6-month hypometabolism in frontal, temporal, cingulate cortex and striatum were associated with individual baseline hippocampal volumes. In TG, 6-month hypometabolism in the amygdala, basal forebrain, cingulate cortex and striatum were associated with individual baseline hippocampal volumes. Conclusions:While hippocampal volumes predict metabolic declines in fronto-cortical regions inWT, in TG carriers of brain amyloidosis, such associations predominate in limbic regions. These results support the vulnerability of limbic cortex to brain amyloidosis.