Abstract
Background: Cerebral Aspergillosis is an opportunistic fungal infection. It reaches by a hematogenous pathway or by paranasal sinuses. Furthermore, the diagnosis is delayed due to the nonspecific clinical signs. Objectives: This study aims to highlight cerebral invasive aspergillosis as a diagnostic hypothesis in a difficult-to-diagnose and nonspecific neurological clinical scenario. Design and setting: This is a literature review from the Escola de Medicina Souza Marques‘s students, Brazil. Methods: The used articles were published between 2016 to 2021, from UpToDate, Journal of Oncology Pharmacy Practice, Elsevier, and Google Academic databases. Results: In immunosuppressed individuals, it manifests as single or multiple brain abscesses with vascular invasion, posing as a life-threatening factor. Immunocompetent patients may respond differently, presenting with meningitis or granulomatous mass, associated with seizures, headache, and visual acuity impairment. MRI or PCR in cerebrospinal fluid is the most used for diagnosis. T2 hypodensity, irregular margins with intracavitary projections on MRI, and absence of the choline peak suggest a fungal etiology. The histopathological study is not common in clinical practice. The recommended treatment is voriconazole in association with echinocandins, for 6 to 12 weeks. Notably, the mortality rate of cerebral aspergillosis in patients who are taking Ibrutinib for other conditions is close to 90%. Conclusion: Therefore it is essential to recognize the complication to avoid morbidity and mortality in immunosuppressed and immunocompetent individuals.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation
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