Cerebral and splanchnic near-infrared spectroscopic dataset in premature newborns receiving packed red blood cell transfusion

Abstract

This article presents the near-infrared spectroscopy (NIRS) dataset of cerebral (StO2c) and splanchnic (StO2s) oxygenation in 29 stable premature infants admitted to a tertiary neonatal intensive care unit who received elective packed red blood cell transfusion (PRBCT) to treat anemia of prematurity.StO2c and StO2s data were prospectively recorded continuously from at least 4 hours before the beginning of PRBCT until 24 hours after its completion, using a 4-wavelength near-infrared spectroscopy (NIRS) monitor (FORE-SIGHT® absolute cerebral oximeter, CASMED, Branford, Connecticut, 06405 USA). StO2 data were downloaded as an analog output at a sampling rate of 1000Hz and aligned along the time axis in LabChart reader format (.adicht files) using a PowerLab data acquisition system [1] (PowerLab®, ADInstruments, Sydney, Australia). The .adicht files were then converted into .mat file format using a Python script (PythonTM version 3.7.3 [2]) and resampled at 1Hz for faster processing.Data that could not be physiologically explained (e.g., the absence of variability, [3] a 30% step change in StO2 between two subsequent data points for StO2[4]), as well as the data during the period of ‘cares’ were presumed to be artefactual and were replaced with ‘NaN’ or ‘Not a Number’ which is recognised by Matlab [5] (MATLAB 9.3, The MathWorks, Inc., Massachusetts, United States) and ignored for all subsequent processing while maintaining the correct time point of the StO2 signals. The data were then exported into Microsoft Excel format. The splanchnic cerebral oxygenation ratio (SCOR) was calculated as the ratio of StO2s/StO2c. A 4-hour mean pre-transfusion values (StO2s 0, StO2c 0, SCOR 0) and post-transfusion hourly mean values (1-28) were determined. Secondary data were derived from a Mixed Models for Repeated Measures (MMRM) analysis with the time point fitted as a fixed effect and the infant fitted as a random effect. The MMRM was used to perform paired comparisons between pre-transfusion and each of the post-baseline values.This article only provides the NIRS data. The secondary data and demography can be found in the article “Splanchnic-Cerebral Oxygenation Ratio associated with Packed Red Blood Cell Transfusion in preterm infants”, published in Transfusion Medicine. [6] The data will be of use to researchers in neonatology, transfusion medicine, and physiology to understand changes in cerebral and splanchnic oxygenation associated with PRBCT. Data collection, processing, and analysis can be remodelled in larger multicentric randomised controlled studies to evaluate the effect of transfusion and feeding on transfusion-associated necrotising enterocolitis. The data are also helpful to explore the autoregulatory behaviour of the brain and gut when the oxygen content of blood is increased by administering PRBCT.