Abstract
Changes which occur in the concentrations of certain amino acids in rat brain during fluoroacetate poisoning, insulin hypoglycaemia and thiopentone anaesthesia have been measured. Fluoroacetate poisoning causes a reduction in the cerebral glutamic acid and aspartic acid levels, and an increase in the alanine concentration. Both insulin hypoglycaemia and thiopentone anaesthesia produce a reduced glutamic acid content and a rise in the aspartic acid level.
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