Abstract
An event-related paradigm was used to investigate the fMRI signal from the primary motor cortex (M1) and the supplementary motor area (SMA) during isolated isometric wrist extension at five different force levels. There was only a weak trend towards increased area of activation with increased force output, but there was a force-related increase in percentage change of signal within voxels in M1 (Kendall Tc = 0.48, p < 0.01), which may indicate control of force output by variation of neural firing rate. In SMA there was a correlation between peak force output and time-to-peak of the haemodynamic response in SMA (Kendall Tc = 0.74, p < 0.0001). This unexpected finding of a task-related change in the shape of the haemodynamic response within a single brain area requires further investigation. It may indicate a slower rise time at lower perfusion rates, or may be the result of inhibitory processes in motor control.
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