Cerebral activating properties of indeloxazine hydrochloride

Abstract

The cerebral-activating properties of indeloxazine hydrochloride [(±)-2-[(inden-7-yloxy) methyl]morpholine hydrochloride, YM-08054] were examined in comparison with those of calcium hopantenate (a cerebral metabolic enhancer), dihydroergotoxine (a cerebral vasodilator), viloxazine and amitriptyline (antidepressants). Indeloxazine enhanced the acquisition of learned behavior (passive avoidance, active avoidance and maze learning) and desynchronized the spontaneous EEG in rats. Amnesia in scopelamine-treated rats, disturbances of consciousness in concussed mice and synchronized EEG in rabbits with lesions of the internal capsule were improved by the administration of indeloxazine. Calcium hopantenate and dihydroergotoxine also showed cerebral-activating properties in the majority of behavioral and electroencephalographic paradigms; however neither improved scopolamine-induced amnesia and calcium hopantenate had no effects on learning. Neither viloxazine nor amitriptyline enhanced the acquisition of learned behavior. The results indicate that indeloxazine possesses activating effects on cerebral functions, including learning and the EEG, and that the pharmacological profile of indeloxazine is wider than those of dihydroergotoxine and calcium hopantenate in cerebral-activating activity.