Cerebellar Structure Across Early and Chronic Stages of Illness in Schizophrenia Spectrum Disorders and Psychotic Bipolar Disorder

Abstract

Psychotic disorders, including schizophrenia-spectrum and psychotic bipolar disorders, are characterized by abnormalities in cerebral structures that may result, at least in part, from abnormal brain development. Prominent neural models hypothesize that the cerebellum also contributes to psychosis pathophysiology, especially schizophrenia. However, the presence of structural cerebellar abnormalities in psychosis remains unclear, including whether cerebellar abnormalities are transdiagnostic and present in early-stage psychosis.