Abstract
BackgroundCerebellar liponeurocytoma is a rare tumor of the central nervous system occurring mainly in the posterior fossa, which shows neuronal and variable astrocytic differentiation with foci of lipomatous differentiation. Liponeurocytoma develops in adult patients and is defined in the World Health Organization classification of 2016 as a rare benign grade II tumor.Case presentationA 39-year-old Italian man presented to our department suffering from headache and nausea. Magnetic resonance imaging revealed a right-sided cerebellar lesion showing poor contrast enhancement without an obstructive hydrocephalus. Surgery was indicated and total tumor resection was achieved. He was discharged without any neurological deficits. Histopathological examinations revealed a cerebellar liponeurocytoma. A neurological follow-up examination revealed no neurological deficit directly after surgery and 1 year later. Radiotherapy was recommended at the neurooncological board despite the total removal of the tumor, but our patient refused adjuvant radiotherapy. Magnetic resonance imaging of his neurocranium with and without contrast enhancement 48 hours after surgery and 15 months after surgery showed no residual tumor.ConclusionsLiponeurocytomas are rare benign tumors occurring in the majority of cases in the cerebellum. The therapy of choice is surgery. Postoperative radiotherapy has to be discussed individually, but seems to be sufficient if complete tumor resection is not achieved or in cases of a tumor recurrence.
Highlights
Cerebellar liponeurocytoma is a rare tumor of the central nervous system occurring mainly in the posterior fossa, which shows neuronal and variable astrocytic differentiation with foci of lipomatous differentiation
Liponeurocytomas are rare benign tumors occurring in the majority of cases in the cerebellum
Gembruch et al Journal of Medical Case Reports (2018) 12:170. This case report presents a rare case of a liponeurocytoma located in the posterior fossa and summarizes the typical radiological and histopathological features of this rare tumor entity
Summary
Liponeurocytomas are rare benign tumors occurring mainly in the cerebellum. They show a different genetic pathway compared to central neurocytomas and medulloblastomas. Surgery is the primary therapy of choice. Adjuvant radiotherapy seems to be sufficient to avoid a tumor recurrence
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