Abstract
Cerebellar Liponeurocytoma Presenting with Fatal Tumor Hemorrhage
Highlights
Cerebellar liponeurocytoma is a very rare neoplasm of the adults, first described by Bechtel, et al in 1978 [1], as mixed mesenchymal and neuroectodermal tumor
This article reports a rare case of cerebellar liponeurocytoma presenting with fatal tumor hemorrhage and discusses the differential pathological diagnosis
A 49-years-old woman had a history of arterial hypertension and chronic renal insufficiency treated by failed kidney transplant one month before and dialysis since 2011; besides, she was in therapy with clopidogrel and acetylsalycilic acid because of deep arterial thrombosis
Summary
Cerebellar liponeurocytoma is a very rare neoplasm of the adults, first described by Bechtel, et al in 1978 [1], as mixed mesenchymal and neuroectodermal tumor. The term “liponeurocytoma” was first introduced in the 2000 World Health Organization as “a distinct clinico-pathological entity in the group of glioneuronal tumors” [2] It is defined as a WHO grade II tumor with neuronal consistent, variable astrocytic and focal lipomatous differentiation and with infiltrative nature, low proliferation index, but high likelihood of recurrence [3,4]. This article reports a rare case of cerebellar liponeurocytoma presenting with fatal tumor hemorrhage and discusses the differential pathological diagnosis. An urgent computerized tomography (CT) (Figure 1a) at our hospital revealed a 42 mm hematoma of the left cerebellar hemisphere, with calcifications and perilesional edema, causing compression of the brainstem and triventricular hydrocephalus. In the first postoperative day a CT scan revealed a blood collection in the surgical cavity, enlarged ventricular system and edema of the pons and medium cerebellar peduncle. The histological and immunohistochemical findings allowed the diagnosis of liponeurocytoma
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