Abstract
AbstractThe drug delivery system (DDS) is a hot spot in the field of medicine due to their favorable characteristics, such as the realizability of targeted therapy, sustained and controlled release of drug. Ceramic materials have abundant desirable properties, such as simple preparation, adjustable size and structure, surface area to volume ratio, desirable stability under physiological conditions and excellent biocompatibility, etc. Hence they have been successfully applied in the field of DDS considerably in decades, acting as drug carriers. Traditional ceramic materials refer to inorganic solid compound. They are mainly composed of carbides, oxides such as hydroxyapatite, tricalcium phosphate, silica, zeolite, and zirconia, etc. This review summarized the applications of the ceramic materials in the field of DDS in recent years, meanwhile the outlooks of future development were also proposed.
Highlights
The drug delivery system (DDS) is the composite of drug and carrier where drugs are loaded inside or on the surface of the carriers through chemical or physical methods [1,2,3,4]
This review summarized the applications of the ceramic materials in the field of DDS in recent years, the outlooks of future development were proposed
The system that OIC-A006 was loaded by PLGA/β-TCP scaffolds with PLGA nanoparticles was favorable to osteoinduction and bone formation
Summary
The drug delivery system (DDS) is the composite of drug and carrier where drugs are loaded inside or on the surface of the carriers through chemical or physical methods [1,2,3,4]. The ceramic-based drug carriers have attracted increasing attention with the developments in medicine, pharmaceutics, and material science. Biodegradability and biological stability; 3.Some ceramics are sensitive to environment, which can response to light, magnetism or heat, etc These characteristics make them feasible for accurate targeted. Great attention of investigators from the fields of biomaterial, biophysics, biochemistry, bioengineering, pharmaceutics and medicine They mainly refer to hydroxyapatite, tricalcium phosphate, silica, zeolite, and zirconia, etc [10]. Β-TCP can be manufactured to hollow structure with certain shape and size They can degrade gradually in physiological environment under the action of body fluids, enzyme or cell. Exploring DDS for controlled, sustained and targeted release of anti-cancer drugs has attracted much attention from various fields to meet clinical requirements that maximum therapy effects along with minimal side effects
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