Abstract
Drug-induced neutropenia is characterized by a sharp decrease in the absolute neutrophil count (ANC) to <500/mm3; agranulocytosis is said to be present once the granulocyte count reaches zero. Although associated with a large variety of drugs, this adverse effect is rare, occurring in 2.4–15.4 cases per million courses of therapy [1]. Because of its efficacy and relative safety, ceftriaxone is commonly used for treating a broad range of serious infections [2]. In this report, we describe a patient who developed agranulocytosis during treatment with ceftriaxone and recovered after treatment was changed to cefepime, and we review previously reported cases of ceftriaxone-induced agranulocytosis.
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