CEPHALOSPORIN ANTIBIOTIC RESISTANCE

Abstract

BACKGROUND: Antibiotics have helped people to treat many diseases and have made the treatment of patients much easier. However, due to the development of resistance factors, antibiotics have become less effective against bacteria. Antimicrobial resistance is one of today's most important issues in global medicine. OBJECTIVE: to determine the expression of cephalosporin drug resistance in an inpatient setting. METHODS: This study was conducted at the Clinical Hospital of Emergency Medical Care Tver, Russia, for the period 2018-2020. Using the standard method of bacteriological examination, the microbiome of 624 patients was examined. The next step was to determine the level of antibiotic resistance. RESULTS: Microorganisms of different spectrum, including Pseudomonas aeruginosa, Escherichia coli, Acinetobacter, etc., were isolated from clinical samples during the study. All microorganism groups showed decreased susceptibility to the drugs used in the study. Ceftriaxone (a third-generation cephalosporin) had the greatest loss of potency (reduction to 0% for all isolates in the study). Cefoperazone sulbactam and ceftazidime rapidly lost activity in this study. Increasing resistance to cefepime (a fourth-generation cephalosporin) was observed. CONCLUSIONS. The study results indicate the rapid spread of resistance among a wide range of pathogenic microorganisms to the studied cephalosporin groups. Complete resistance developed within three years to the third-generation cephalosporins. A decrease in the susceptibility to the fourth generation of cephalosporins was observed.