Abstract

Under the electron microscope,the eentrosome consists of centriole and peri-centriolar material (PCM) . PCM is composed of a series of proteins and fibers. Most of the centrosome function are carried out by these proteins.As a member of centrosomal proteins family,the Cep63 has been studied with great progress in recent years.The Cep63 is ahnost exclusively localized to centrosomes throughout the cell cycle.Together with Cep152 and Cep57,they form a ring-like structure,which lies around the proximal end of centriole,and functions in centrosome duplication,spindle assemble and G2 / M transition mechanism.Abnormal expression of Cep63 has been reported to be associated with several kinds of tumors and primary microcephaly.In view of the role of Cep63 in mitosis,the study of its location and function in meiosis will favor the exploration of the oocyte maturation mechanism in vitro,and eventually may help for the development of reproductive medicine in the future. Key words: Pericentriolar material ; Centrosomal protein-cep63 ; Primary microcephaly

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