Abstract
The centromere is a unique region of the chromosome that defines the site of kinetochore assembly and is essential for the faithful segregation of the sister chromatids into the 2 daughter cells. While the kinetochore only forms as a transient structure during mitosis, the centromere persists as a stable domain throughout the cell cycle, bound by proteins of the constitutively centromere associated network (CCAN).1 Interphase centromeres have been described to cluster together and associate with the periphery of the nucleolus depending on cell cycle stage, cell type, and organism.2,3
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