Abstract
Centrocytic lymphoma is a CD5-positive B cell neoplasm defined in the Kiel classification (Figure 1) [1]. This lymphoma, composed of cells resembling centrocytes (cleaved follicular center cells), is distinguished from other small cleaved cell lymphomas by the lack of transformed cells, the diffuse, vaguely nodular, or mantle zone growth pattern, and immunophenotypic differences (CD5+, CD10-, and strong surface IgM and/or IgD expression) [1, 2]. Transformation to non-cleaved or centroblastic (large cell) lymphomas is rare. Patients are usually males 50&3x2013;70 years of age, who generally present with diffuse lymphadenopathy, splenomegaly, and marrow involvement, and have a median survival > 4 years.KeywordsMantle Cell LymphomaParathyroid Adenoma11q13 BreakpointDiffuse LymphadenopathyFollicular Center CellThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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