Abstract
Inflammatory molecules such as histamine increase endothelial permeability by initiating retraction of adjacent endothelial cells. We recently reported that in human umbilical vein endothelial (HUVE) cells histamine increased phosphorylation of the light chain of myosin (MLC) by 0.18 ± 0.02 moles phosphate per mole MLC (molP/molMLC). This is consistent with the hypothesis that histamine initiates retraction by increasing centripetal tension within endothelial cells. However, chelation of extracellular calcium which interrupts cellcell and cell-substrate binding also increases endothelial permeability and causes endothelial cell retraction both in situ in perfused lungs and in vitro with cultured cells.
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