Abstract
M. J. Antonaccio, M. Asaad and J. Boccagno, Centrally mediated pressor response to metiamide as a result of GABA-receptor antagonism, European J. Pharmacol. 72 (1981) 369-372.The mechanism of the pressor response to metiamide was examined in anesthetized cats. Intravenous administration of metiamide had no effect on blood pressure. Infusion into the lateral ventricle (10 mg/kg/min for 10 min), caused a marked pressor response which was due to an increase in sympathetic outflow since pretreatment of cats with guanethidine completely prevented it. In a rat brain synaptosome preparation, both metiamide and cimetidine displaced [3H]GABA. These data strongly suggest that metiamide increases blood pressure in the cat through a central mechanism involving GABA-receptor antagonism.
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