Abstract
It has been shown that: (1) isoprenaline (15 μg doses) when injected into the lateral cerebral ventricle of the cat produces a decrease in the mean blood pressure and an increase in heart rate which are quantitatively repeatable, (2) intraventricular reserpine (500 μg) given 24 hr previously increases responses to small doses (1.5 μg) of isoprenaline and does not alter responses to high doses (15 μg), (3) previous intraventricular injections of pronethalol (300 μg) or propranolol (30 μg) significantly reduce responses to isoprenaline (15 μg); a dose of 30 μg of pronethalol exerts no effect, (4) central pretreatment with phenoxybenzamine (2 mg) does not modify the responses observed following isoprenaline, and (5) spinal C-2 section abolishes the cardiovascular actions of isoprenaline. These findings would suggest the possible existence of specific central nervous system beta-adrenergic-like mechanisms mediating similar types of peripheral autonomic functions, although further studies on this question are necessary.
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