Central-to-axial chirality transfer and induced circular dichroism in 6,7-dihydro-5 H-dibenz[ c, e]azepine derivatives of α- and β-amino esters

Abstract

DAZ-Xaa ∗-OMe amino ester derivatives with Xaa ∗ = d/ l-Ala, d/ l-Val, l-Leu, l-Ile, l-Ser, l-β 3-HAla, l-β 3-HVal, l-β 3-HLeu, (1 S,2 S)/(1 R,2 R)-ACHC (2-aminocyclohexanecarboxylic acid) and (1 S,2 S)/(1 R,2 R)-ACPC (2-aminocyclopentanecarboxylic acid), N-blocked as 6,7-dihydro-5 H-dibenz[ c, e]azepines (DAZ), have been synthesized and evaluated for the determination of the absolute configuration of α- and β-amino esters through the induced circular dichroism of the biphenyl chromophore.