Abstract
Confirming earlier research, Maudsley Reactive (MR) male rats had higher concentrations of serotonin (5-hydroxytryptamine) in brain stem than did Maudsley Nonreactive (MNR) rats. Comparisons of MR with a second MNR substrain (MNRA) revealed no strain differences in brain stem serotonin. The two MNR substrains exhibit similar levels of open-field defecation, and both differ substantially from MR animals. The present results suggest that, contrary to previous claims, brain stem serotonin is not consistently related to open-field defecation in the Maudsley strains.
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