Abstract
We found that prostaglandin (PG) D 2, the most abundant PG in the central nervous system, stimulates food intake after intracerebroventricular administration in mice. The orexigenic effect of PGD 2 was mimicked by a selective agonist for the DP 1 receptor among two receptor subtypes for PGD 2, and abolished by its antagonist. Central administration of an antagonist or antisense oligodeoxynucleotide for the DP 1 receptor remarkably decreased food intake, body weight and fat mass. Hypothalamic mRNA levels of lipocalin-type PGD synthase were up-regulated after fasting. The orexigenic activity of PGD 2 was also abolished by an antagonist for neuropeptide Y (NPY) Y 1 receptor. Taken together, PGD 2 may stimulate food intake through central DP 1 receptor coupled to the NPY system.
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