Abstract
Introduction: Central Odontogenic Fibroma (COF) is a rare benign odontogenic tumour of the jaws. Until its recent change in classification by the WHO in 2017, this entity has gone without an agreed upon definition for many years. For this reason, COF would remain largely unknown to practitioners. Corpus: The pedagogical objectives of this article are, through a systematic review of the literature using the PRISMA methodology, to list the epidemiological, aetiological, clinical, radiological, histological, therapeutic and prognostic characteristics of COF. All the data collected made it possible to establish a COF management summary for practitioners in order to optimize it. Conclusion: Based on the 135 cases listed, it appears that surgical enucleation is the treatment of choice for COF. The recurrence rate is low and malignant transformation has never been reported. However, regular clinical and radiological follow-up of patients over several years seems to be a justified precaution.
Highlights
According to the World Health Organization (WHO), Central Odontogenic Fibroma (COF) is a rare benign odontogenic tumour of mesenchymal origin [1]. This tumour consists of mature connective tissue in which islands or strands of inactive-looking odontogenic epithelium can be found with or without evidence of calcification
Described for the first time by the WHO in 1971, COF has not had a consensual definition for years and its classification has recently undergone changes
The search equation was on Scopus: “KEY (“fibroma”) OR KEY (“Odontogenic tumors”) AND ALL (“central odontogenic fibroma”) AND (LIMIT-TO (DOCTYPE, “ar”) OR LIMIT-TO (DOCTYPE,“re”))”, and on PubMed: “(“Fibroma” [Mesh]) AND (“Odontogenic Tumors” [Mesh]) AND ((Review[ptyp] OR Case Reports[ptyp])”
Summary
According to the World Health Organization (WHO), Central Odontogenic Fibroma (COF) is a rare benign odontogenic tumour of mesenchymal origin [1]. This tumour consists of mature connective tissue in which islands or strands of inactive-looking odontogenic epithelium can be found with or without evidence of calcification. Described for the first time by the WHO in 1971, COF has not had a consensual definition for years and its classification has recently undergone changes. Based on a systematic review of the literature using the PRISMA methodology, we collected and analysed the various cases of COF in order to optimize its management. The educational objectives are: – To update the epidemiological data on COF
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