Central odontogenic fibroma: a case report with long-term follow-up

Marco T Brazão-Silva,Antônio F Durighetto-Júnior,Adriano M Loyola,Alexandre V Fernandes,Sérgio V Cardoso

doi:10.1186/1746-160x-6-20

Marco T Brazão-Silva, Antônio F Durighetto-Júnior + Show 3 more

Open Access

https://doi.org/10.1186/1746-160x-6-20

Copy DOI

Abstract

An osteolytic tumour of the mandible with prominent expansive growth on the alveolar ridge and displacement of the involved teeth is described in a 28-year-old man. The lesion was diagnosed as a central odontogenic fibroma, an uncommon benign neoplasm derived from dental apparatus, and was removed by curettage. The patient remains asymptomatic after thirteen years of follow-up, which supports the claimed indolent behavior of this poorly documented disease and the adequacy of a conservative surgical treatment.

Highlights

Central odontogenic fibroma (COF) is an uncommon benign neoplasm composed by varying amounts of inactive-looking odontogenic epithelium embedded in a neoplastic mature and fibrous stroma [1,2,3,4,5,6,7,8,9,10,11,12]
Due to its non-exclusive histological features, this lesion may be confused with other entities, such as hyperplastic dental follicles, odontogenic myxomas, and desmoplastic fibromas, which highlight the importance of clinicopathological correlation in the diagnosis of odontogenic fibromas [2,3,7,12,13]
In spite of central odontogenic fibroma be usually removed, not showing any adherence to bone and/or tooth structure, the recurrences were related to insufficient curettage

Summary

Introduction

Central odontogenic fibroma (COF) is an uncommon benign neoplasm composed by varying amounts of inactive-looking odontogenic epithelium embedded in a neoplastic mature and fibrous stroma [1,2,3,4,5,6,7,8,9,10,11,12]. This variant shows abundant islands and strands of apparently inactive odontogenic epithelium and spindle or stellate fibroblasts Their parenchyma is composed by a connective tissue constituted by interposed bundles of collagen alternating with less cellular and less fibrous regions [1,2,3]. In spite of central odontogenic fibroma be usually removed, not showing any adherence to bone and/or tooth structure, the recurrences were related to insufficient curettage Because of their benign slow growth characteristic, a clinical identification of recurrence or residual disease could be identified only several years after [26]. We proved here that this is not necessary if a diagnosis of COF is well conducted

Conclusion

Findings

32. Awange DO