Abstract
ContextThe association between obesity and Helicobacter pylori (H. pylori) infection remains controversial.AimsThe objective is to investigate the relationship between obesity and H. pylori infection, as diagnosed on the basis of a 14C urea breath test (14C-UBT) and waist circumference (WC).Settings and designA retrospective cross-sectional study was performed at Health management center of a Tertiary care teaching hospital in Southwest of China.Materials and methodsClinical information of 76,915 individuals (46,003 men and 30,912 women) with 44.0 (35.0–51.0) years was extracted from medical record. H. pylori infection was diagnosed by a positive 14C-UBT, and obesity was defined as WC ≥ 90 cm in men and ≥ 80 cm in women.Statistical analysisDescriptive statistics, Student’s t test, Mann-Whitney U test, and chi-square test, followed by binary logistic regression were performed in SPSS.ResultsThe overall prevalence of H. pylori infection was 39.95%. The prevalence of H. pylori infection in subjects with central obesity was significantly higher than that in normal-WC subjects (42.20% vs. 39.10%, p < 0.001). WC was significantly higher in H. pylori-positive subjects compared with H. pylori-negative subjects (p < 0.01). There was a linear association between WC quintiles and H. pylori infection prevalence. After adjusting for confounders, central obesity was associated with H. pylori infection (OR = 1.052, 95% CI, 1.009–1.096, p = 0.02).ConclusionsCentral obesity is associated with H. pylori infection after adjusting for multiple confounding factors such as age, gender, and lifestyle characteristics.
Highlights
Helicobacter pylori (H. pylori) infection affects almost half of the world’s population
In order to explore the association between H. pylori infection diagnosed by 14C urea breath test (14C-UBT) and obesity diagnosed on the basis of waist circumference (WC), we conducted a large-scale cross-sectional retrospective study in West China
Height, body mass index (BMI), WC, hip circumference (HC), systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure(PP), fasting blood glucose (FPG), Low-density lipoproteins cholesterol (LDL-C), triglycerides (TG), total cholesterol (TC), uric acid (UA), serum creatinine (Scr), blood urea nitrogen (BUN), aminotransferase (ALT), γglutamyltransferase (γ-GGT), aspartate aminotransferase(AST), and prevalence of smoking, alcohol use, hypertension, and diabetes mellitus were significantly higher, but the high-density lipoproteins cholesterol (HDL-C) level was significantly lower in subjects with central obesity compared with normal-WC subjects
Summary
Helicobacter pylori (H. pylori) infection affects almost half of the world’s population. H. pylori infection contributes to a variety of gastrointestinal diseases, such as chronic gastritis, peptic ulcer, gastric cancer, and gastric mucosa-associated lymphoma (MALT). H. pylori infection plays a role in extragastric diseases, such as cardiovascular and immunological systemic disorders. Chronic spontaneous urticaria and insulin resistance [1] have been found to be associated with H. pylori infection. 14C urea breath test (14C-UBT) was a simple invasive methods with high sensitivity 0.96 (95% CI 0.95– 0.97) and specificity 0.93 (95% CI 0.91–0.94) to detect H. pylori infection [15]. In order to explore the association between H. pylori infection diagnosed by 14C-UBT and obesity diagnosed on the basis of WC, we conducted a large-scale cross-sectional retrospective study in West China
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