Abstract
Male rats were given 6-hydroxydopamine-induced lesions of the locus coeruleus (LC) or the dorsal nor-adrenergic bundle (DNAB), prior to the measurement of locomotor and rearing activity induced by d-amphetamine. The increased locomotor activity induced by d-amphetamine (1.8 mg/kg) was significantly attenuated by both the LC and the DNAB lesions. The stimulatory effect of the 7.2 mg/kg dose of amphetamine was attenuated by the LC lesion, whereas the DNAB lesion potentiated this effect. The LC lesion also attenuated rearing induced by the 7.2 mg/kg dose of amphetamine. These results suggest some involvement of central noradrenergic neurons in the activity induced by amphetamine in the rat.
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