Abstract
Phernic nerve responses to intravenous administration of sodium salicylate were measured in anesthetized, paralyzed cats whose vagi and carotid sinus nerves had been cut. Three groups of animals were studied. One consisted of animals with intact central nervous systems. The other two were identical except that the spinal cords had been transected at either T 4−T 5 or C 7−T 1. Salicylate led to a significant increase in respiration and whole body metabolism in all groups. Transection of the spinal cord had no effect on the magnitude of the respiratory response to salicylate. We also studied another group of animals in which salicylate was injected directly into the third cerebral ventricle. This led to a significant increase in respiration without an increase in whole body metabolism. We conclude that salicylate stimulates respiration by a mechanism other than one related to its ability to increase whole body metabolism and that this mechanism is located within the central nervous system.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
