Abstract
IgG4-related disease is a new and recently described and determined disease involving multiple organs. Its etiology and pathogenesis are still not fully understood. However according to multiple studies this disease should be considered as a unique pathological autoimmune unity involving various organs and tissues. IgG4-reladted disease was first considered as a form of pancreatic inflammatory process and diagnosed as IgG4-related autoimmune pancreatitis. However current data demonstrate the potential involvement of almost all tissues and organs including central nervous system. Diagnostic criteria are being reviewed annually resulting in IgG4-related disease diagnosis in many considered differently cases. This review presents current literature data related to IgG4-related disease etiology and pathogenesis, diagnostic criteria and potential forms of central nervous system IgG4-related injury.
Highlights
IgG4‐reladted disease was first considered as a form of pancreatic inflammatory process and diagnosed as IgG4‐related autoimmune pancreatitis
Diagnostic criteria are being reviewed annually resulting in IgG4‐related disease diagnosis in many considered differently cases
This review presents current literature data related to IgG4‐related disease etiology and pathogenesis, diagnostic criteria and potential forms of central nervous system IgG4‐related injury
Summary
Поражение центральной нервной системы при IgG4‐ассоциированном системном заболевании: обзор литературы. This review presents current literature data related to IgG4‐related disease etiology and pathogenesis, diagnostic criteria and potential forms of central nervous system IgG4‐related injury. Активность заболевания варьирует, при этом может иметь место поражение как одного органа, так и двух и более органов одной или нескольких систем [1]. На протяжении многих лет IgG4‐АСЗ рассматривали только как патологию поджелудочной железы, однако совсем недавно – с конца 2000‐х годов – получены доказательства распространенного характера заболевания и наличия его проявлений в других системах органов, в том числе в центральной нервной системе. В конце 1960‐х годов был впервые описан случай семейного мультифокального фибросклероза с развитием очагов медиастинального и ретроперитонеального фиброза, склерозирующего холангита, тиреоидита и псевдоопухоли глазницы без вовлечения в процесс поджелудочной железы [10]. Okazaki и соавт. [5] c исправлениями)
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