Abstract
Adrenocorticotropic Hormone (ACTH), Melanocyte-Stimulating Hormone (MSH), and related peptides have been shown to have several neurogenic effects: alteration of cerebral protein synthesis, RNA synthesis, protein phosphorylation, and neurotransmitter turnover. Furthermore, there appears to be an ACTH containing circuit in the CNS which originates in the arcuate nucleus. Changes in concentration of the peptides in this family have been shown to alter electrophysiology, neuromuscular function, and behavior (e.g., grooming, learning) in infrahuman subjects. These findings suggest that the neuropeptides MSH and ACTH influence the capacity of an organism to efficiently evaluate information and influence the affective functioning of humans.
Highlights
Changes in concentration of the peptides in this family have been shown to alter electrophysiology, neuromuscular function, and behavior in infrahuman subjects. These findings suggest that the neuropeptides Melanocyte-Stimulating Hormone (MSH) and Adrenocorticotropic Hormone (ACTH) influence the capacity of an organism to efficiently evaluate information and influence the affective functioning of humans
ADRENOCORTICOTROPIC hormone (ACTH) is a linear nonatriacontapeptide, i.e. a peptide consisting of 39 amino acid residues, which can be derived from a larger 31,000 dalton glycoprotein [77] and is but one member of a chemically and biogenetically related family of polypeptides which includes melanocyte-stimulating hormone (MSH)
A large number of studies suggest that there are corticosteroid receptors in many areas of the limbic system. Together these findings indicate that limbic system circuits may be an important first place to look if one wants to find the neuroendocrine regulatory mechanism for attention
Summary
Printed in the U.S.A. Central Nervous System and Peripheral Effects of ACTH, MSH, and Related Neuropeptides. Central nervous system and peripheral effects of ACTH, MSH, and related neuropeptides. PEPTIDES 3(3) 411--420, 1982.--Adrenocorticotropic Hormone (ACTH), Melanocyte-Stimulating Hormone (MSH), and related peptides have been shown to have several neurogenic effects: alteration of cerebral protein synthesis, RNA synthesis, protein phosphorylation, and neurotransmitter turnover. Changes in concentration of the peptides in this family have been shown to alter electrophysiology, neuromuscular function, and behavior (e.g., grooming, learning) in infrahuman subjects. These findings suggest that the neuropeptides MSH and ACTH influence the capacity of an organism to efficiently evaluate information and influence the affective functioning of humans
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