Abstract
Dimethylaminomethyleneisobenzofuranones react with alkoxyphenylethylamines in aqueous acidic solution to give phthalide isoquinolines (tetrahydroisoquinolinylisobenzofuranones) in moderate yields. N-Methylation gives the naturally occurring phthalideisoquinoline alkaloids. A number of examples of this reaction sequence are reported, including the synthesis of (�)-cordrastine, (�)-corlumine and (�)-adlumine.
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