Abstract
sBackgroundOur goal was to analyze the incidence of level VI metastasis in previously untreated oral squamous cell carcinoma (SCC) patients and their clinicopathological and prognostic characteristics.MethodsOral SCC patients with level VI metastasis were retrospectively enrolled, and their demographic and pathologic features as well as their survival data were descriptively analyzed.ResultsA total of 13 cases from 1875 patients were included, all patients had SCC at the floor of mouth (SCCFOM). Eight (61.5%) patients had a pT4 tumor, and all patients had a pathological N3 neck with multiple positive lymph nodes. Adverse pathologic features were present in 100% of the patients. The size of the metastatic foci in level VI ranged from 2.6 cm to 4.5 cm with a mean value of 3.2 cm, and 5 patients showed a soft tissue deposit with no lymph node component. Recurrence occurred in all patients, and 11 patients died of uncontrolled cancer within 5 years after surgery.ConclusionLevel VI metastasis in primary oral SCCFOM is rare, and its prognosis is poor.
Highlights
Oral squamous cell carcinoma (SCC) is the most common malignancy in the head and neck [1]. It is characterized by aggressive biological behaviors and regional metastasis, and almost half of patients with oral SCC have neck lymph node metastasis at the time of diagnosis [2, 3]
Enrolled patients met the following criteria: the disease was primary and treated by surgery; detailed pathologic information of the primary tumor could be obtained; level VI metastasis was confirmed by postoperative surgical pathology; and there was no SCC arising from other sites
A total of 13 cases from 1875 patients with surgically treated primary oral SCC were enrolled for analysis, with an incidence of 0.69%
Summary
Oral squamous cell carcinoma (SCC) is the most common malignancy in the head and neck [1]. It is characterized by aggressive biological behaviors and regional metastasis, and almost half of patients with oral SCC have neck lymph node metastasis at the time of diagnosis [2, 3]. Shah et al [7] previously summarized their experience at the Memorial Sloan-Kettering Cancer Center in treating 1081 primary patients with SCC of the upper aerodigestive tract, in which 501 oral SCC patients received 516 radical neck dissections. Our goal was to analyze the incidence of level VI metastasis in previously untreated oral squamous cell carcinoma (SCC) patients and their clinicopathological and prognostic characteristics
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