Abstract
In rodents and goldfish, ghrelin is well known as an orexigenic peptide, and des-acyl ghrelin, which is a ghrelin gene-derived peptide lacking Ser-3 acylation, affects feeding behavior when injected with or without ghrelin. Intracerebroventricular (ICV) injection of ghrelin inhibits food intake in chicks ( Gallus gallus), but has the opposite effect in rodents and goldfish. The aim of the present study was to investigate the effect of chicken des-acyl ghrelin on feeding in chicks. ICV injection of des-acyl ghrelin alone at doses from 4 to 1000 pmol did not affect food intake in fed and 12-h fasted chicks. Co-injection of des-acyl ghrelin with ghrelin tended to attenuate ghrelin-induced anorexia. In an in vitro study, only the highest concentration (10 −6 M) of des-acyl ghrelin increased intracellular calcium ion concentration in chicken GHS-R1a-expressing cells. Des-acyl ghrelin (10 −6 M) slightly but significantly decreased intracellular calcium ion influx induced by 1 or 3 nM ghrelin. The present results demonstrate that des-acyl ghrelin is not positively involved in the central regulation of feeding in chicks. The feeding regulatory network between ghrelin and des-acyl ghrelin in chicks would be different from those in rodents and goldfish.
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