Abstract
DNA methyltransferases (DNMTs) regulate gene expression by catalyzing DNA methylation but their role in the brain in regulating sickness behavior induced by neuroinflammation is not known. Therefore, we sought to determine the central effects of demethylation of DNA with a DMNT inhibitor on sickness behavior induced by lipopolysaccharide (LPS). Adult C57 BL/6J mice (age 3–6 months) were implanted with an intracerebroventricular (ICV) cannula, and after 7 days of recovery were injected ICV with saline vehicle or the DMNT inhibitor zebularine (300 ng/μl). Saline vehicle or LPS (10 ng/μl) was injected ICV 30 min later. Burrowing behavior and body weight were measured at 4, 8, 12, 24, and 48 h to assess sickness behavior. LPS reduced burrowing behavior in mice (p
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