Central Hypothyroidism: The Endocrine “Memory” for Dyke–Davidoff–Masson Syndrome

Anda Dumitrascu,Mara Carsote,Cristina Dumitrescu,Ana Valea

doi:10.35995/ceacr2010016

Abstract

Hypothyroidism is a worldwide medical problem, most of the cases being related to primary causes like thyroid autoimmune background or multinodular goiter. A particular form of thyroid hormone insufficiency of the central type is related to Dyke–Davidoff–Masson (DDM) syndrome, which is a severe condition associating hemicerebral hypoplasia or even atrophy, a consequence of a brain injury during the fetal period of time or the first years of childhood. In addition to neurological damage, pituitary function may be affected, requiring hormone replacement.

Highlights

Hypothyroidism is a worldwide medical problem, most of the cases being related to primary causes [with or without] thyroid autoimmune background or multinodular goiter [1,2]
This is a 19-year-old male who is admitted for a central hypothyroidism check-up
His personal medical history includes: birth weight of 3500 g but with neonatal injuries and a severe meningoencefalitis episode complicated with sepsis and a 10-day coma. He developed neurological anomalies: right hemiparesis, epilepsy, and right eye amblyopia. He was confirmed with pituitary dwarfism based on extremely low IGF1 of 9 ng/mL and therapy with growth hormone was offered to the patient but it was not tolerated

Summary

Introduction

Hypothyroidism is a worldwide medical problem, most of the cases being related to primary causes [with or without] thyroid autoimmune background or multinodular goiter [1,2]. Central Hypothyroidism: The Endocrine “Memory” for Dyke–Davidoff–Masson Syndrome Cent. A particular form of thyroid hormone insufficiency of the central type is related to Dyke–Davidoff–Masson (DDM) syndrome, which is a severe condition associating hemicerebral hypoplasia or even atrophy, a consequence of a brain injury during the fetal period of time or the first years of childhood [3].

Results

Conclusion