Central Hemodynamics in the Use of Different Methods for Recovering the Circulating Blood Volume in Hemorrhagic Shock

Abstract

Objective: to study the specific features of correction of central hemodynamics in hemorrhagic shock when various treatments are used. Materials and methods. Experiments were made on 38 mongrel dogs in 4 series of experiments: 1) 12 dogs under hemorrhagic shock (a control group); 2) 10 anemic animals receiving later infusion therapy; 3) 10 anemic dogs exposed to HBO (p02=300 kPa; a 60-min session); 4) 6 anemic dogs receiving complex treatment (HBO and infusion). Circulatory blood volume (CBV), cardiac index (CI), left ventricular stroke output index (LVSOI), heart rate, and blood pressure (BP) were determined in all the animals at the baseline, in 30-, 90-, and 150-min shock (controls) at 5 and 60 min after treatment. Results. In the posthemorrhagic period, all hemodynamic parameters were found to be decreased (p<0.01). After infusion therapy (Series 2), the central hemodynamic parameters with CBV normalization remained at the level of 30-min shock. After oxygenation (Series 3) and complex therapy (Series 4), CBV normalization was attended by the recovery of the study circulatory parameters. This was caused by lower hypoxia, activated myocardial metabolic processes, and stimulated adaptive hemodynamic reactions. Reducing the volume of an infusion mixture in Series 4 animals lowers a cardiac load, provides a positive effect in the treatment of terminal conditions. Conclusion. HBO used in the complex therapy of hemorrhagic shock is an important component ensuring the normalization of metabolic processes and hemodynamic homeostasis in posthemorrhagic states.