CENTRAL GIANT CELL LESION AFFECTING THE MAXILLA: A CASE REPORT

Abstract

Central giant cell lesion (CGCL) is a disease that affects the gnathic bones, predominantly in female patients, usually affecting the anterior region of the mandible. CGCL presents an osteolytic appearance, being locally destructive and aggressive, or presenting a slow growing pattern with bone cortical expansion without bone perforation. The conventional treatment of CGCL comprises the surgical removal of the lesion, varying from curettage to resection depending on its aggressiveness, location, and size. The objective of this study is to report a case of aggressive CGCL involving a 6-year-old male patient who exhibited cortical bone perforation, root resorption, and pain. Laboratory tests of parathyroid hormone and alkaline phosphatase excluded the possibility of brown tumor of hyperparathyroidism and patient has been treated with total surgical resection of the lesion, showing no signs of relapse after 6 months of follow-up. Central giant cell lesion (CGCL) is a disease that affects the gnathic bones, predominantly in female patients, usually affecting the anterior region of the mandible. CGCL presents an osteolytic appearance, being locally destructive and aggressive, or presenting a slow growing pattern with bone cortical expansion without bone perforation. The conventional treatment of CGCL comprises the surgical removal of the lesion, varying from curettage to resection depending on its aggressiveness, location, and size. The objective of this study is to report a case of aggressive CGCL involving a 6-year-old male patient who exhibited cortical bone perforation, root resorption, and pain. Laboratory tests of parathyroid hormone and alkaline phosphatase excluded the possibility of brown tumor of hyperparathyroidism and patient has been treated with total surgical resection of the lesion, showing no signs of relapse after 6 months of follow-up.