Abstract
Central Genes and Signaling Pathways in Colorectal Cancer Are Determined Based on Bioinformatics Analysis
Highlights
Colorectal cancer (CRC) is a heterogeneous disease whose subtypes are characterized by distinct genetic and epigenetic alterations [1]
differentially expressed genes (DEGs) Associated with CRC were Screened from Microarray-Based Gene Expression Databases
The gene expression databases of GSE41328, GSE75970 and GSE89076 were downloaded from the Gene Expression Omnibus (GEO) database to find DEGs
Summary
Colorectal cancer (CRC) is a heterogeneous disease whose subtypes are characterized by distinct genetic and epigenetic alterations [1]. CRC is generally classified into the proximal colon, distal colon and rectal cancer and the tumor genetic and epigenetic features are different by tumor location [4]. Since CRC is basically asymptomatic except that the alarm features develop to an advanced stage, the implementation of the screening programmes is of great importance to lower cancer incidence and mortality rates [8]. Some genes participate in CRC development as have closely correlated with poor prognosis of CRC including KRAS and RAS [9]. We aim to screen out the genes participated in CRC by using bioinformatics analysis
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