Abstract
The present study was performed to investigate effects of central cyclooxygenase (COX) on interleukin (IL)-1β-induced hyperalgesia in the orofacial area. Experiments were carried out on 72 male Sprague–Dawley rats weighing 220–280 g. Surgical procedures were performed under pentobarbital sodium. We examined noxious behavioral scratching responses induced by 50 μl of 5% formalin injected subcutaneously into the vibrissa pad without any restraints. The orofacial formalin responses exhibited two distinct phases with early responses (0–10 min) and continuous prolonged responses (11–45 min). Intracisternal injection of 100 pg IL-1β significantly increased noxious behavioral responses. Pretreatment with indomethacin, a non-selective COX inhibitor, or NS-398, a selective COX-2 inhibitor, blocked IL-1β-induced hyperalgesic responses. However, pretreatment with SC-560, a selective COX-1 inhibitor, did not change hyperalgesic response to IL-1β. These data suggest that central IL-1β modulates the transmission of nociceptive information in the orofacial area and that central COX-2 plays an important role in IL-1β-induced hyperalgesia.
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