Abstract
Corticotropin-releasing factor (CRF) administered as a single dose intraventricularly produces a dose-dependent suppression of rat splenic natural killer (NK) cell activity. Neither systemic CRF nor CRF in vitro significantly altered NK activity. The immunosuppressive effect of central CRF was antagonized by central, but not by systemic, preadministration of the CRF antagonist, α-helical oCRF residues 9–41. These data suggest that CRF released in the brain may have a role in the central modulation of natural killer cytotoxicity.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
