Abstract
During the last decade various antihypertensive drugs were found to lower arterial pressure by activating central noradrenergic neurons with an inhibitory action on the sympathetic nervous system and/or by mimicking the action of norepinephrine at the central adrenoceptors. The presently available data suggest that neurons other than noradrenergic are also involved in the central control of cardiovascular functions. Neurotransmitters, other than norepinephrine, e.g. serotonin, GABA, enkephalins and dopamine may modulate the central control of arterial pressure. Some of the synthetic drugs can conceivably lower arterial pressure by modifying the synthesis, metabolism or activity of these neurotransmitters. This review deals with the central mechanisms of blood pressure control and with the centrally acting antihypertensive drugs.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
