Abstract
Somatostatin (SRIF) is widely distributed throughout the body, and regulates the endocrine system via interactions with various hormones, including the pituitary growth hormone, the thyroid stimulating hormone and the majority of the hormones of the gastrointestinal tract. SRIF is present in the central nervous system (CNS), where it affects rates of neurotransmission, and is also reported to be active in the intestinal tract, with evidence that stressed rats present a significant decrease in antral somatostatin-like immunoreactivity (SLI). Analysis of SRIF has mainly been carried out by means of radioimmunoassay methods. Here, we propose the use of an electrochemical method, such as voltammetry, applied with carbon-based sensors and, in particular, the combination of differential pulse voltammetry with treated carbon fiber micro electrodes (DPV-µCFE) to facilitate the analysis of such peptidergic electro active hormones in the rat striatum and gastric tissue; the effect of growth hormone (GH) and epidermal growth factor (EGF), in particular, upon the SRIF signal has been studied in such tissues.
Highlights
The somatotropin release-inhibiting factor (SRIF) Somatostatin is a hormone distributed throughout the body
SRIF is present in the central nervous system (CNS), where it affects rates of neurotransmission, and is reported to be active in the intestinal tract, with evidence that stressed rats present a significant decrease in antral somatostatin-like immunoreactivity (SLI)
We propose the use of an electrochemical method, such as voltammetry, applied with carbon-based sensors and, in particular, the combination of differential pulse voltammetry with treated carbon fiber micro electrodes (DPV-μCFE) to facilitate the analysis of such peptidergic electro active hormones in the rat striatum and gastric tissue; the effect of growth hormone (GH) and epidermal growth factor (EGF), in particular, upon the SRIF signal has been studied in such tissues
Summary
The somatotropin release-inhibiting factor (SRIF) Somatostatin is a hormone distributed throughout the body. Biosensors 2017, 7, 53 a cyto-protective activity on gastric mucosa [12,13] and, taken together with the evidence that EGF treatment determines levels of antral SLI significantly higher than that in control rats, proposes a role for EGF in preventing stress ulcer formation. It suggests an involvement of the endogenous SLI in its anti-ulcer function. The in vitro oxidation of SRIF, as well as that of structurally related peptides at such potential, has previously been established [18]
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