Abstract
This experiment investigated whether neonatal isolation stress alters central concentrations of progestins. Whole brain progesterone (P), dihydroprogesterone (DHP), and allopregnanolone (3α, 5α-THP) were measured in pups that were isolated from the nest, dam, and siblings for 1 h on postnatal days (PND) 2–9 and were compared to control litters of pups that were not isolated. Isolated 2-day-old pups had significantly lower central P and higher P to DHP and 3α, 5α-THP metabolism ratios. On PND 9, pups that had been repeatedly isolated (PND 2–8), had significantly lower whole brain DHP and significantly greater whole brain 3α, 5α-THP compared to controls. Thus, the biosocial stress of isolation in neonatal rats alters central pregnane steroids.
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