Abstract
We showed that intracerebroventricular (icv) administration of orexins increases arterial blood pressure (ABP), heart rate (HR), and sympathetic outflow in conscious rats. Orexins have been reported to be important mediators in several physiological functions such as feeding behavior, energy expenditure, and the awake–sleep cycle. To examine the possible effects of orexins on the neural activity of the paraventricular nucleus (PVN) of the hypothalamus, an integrative center of the autonomic and endocrine functions related to intero- and exteroceptive stress responses, we simultaneously recorded ABP, HR, and single-unit activity in the PVN in conscious, freely moving rats.
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