Abstract
In this chapter, the influence of various structurally related cholinergic drugs (arecaidine esters) and of nicotine on arterial pressure and cardiac frequency is tested following central administration via the left vertebral artery of the cat. A comparison is made of the effects following intravenous injection. Arecaidine esters possess a central hypotensive action by stimulating central muscarinic receptors in the brain stem but do not influence cardiac frequency. It is postulated that peripheral muscarinic receptors behave in the same way as central muscarinic receptors toward their agonists. After injection into the vertebral artery, nicotine accumulates mainly in the brain stem and causes potent hypotensive and cardio depressive effects by stimulating central nicotinic receptors. The experimental results suggest that acetylcholine may play an important part in the central regulation of blood pressure and heart rate.
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