Abstract
The role of α 2-adrenoceptors in the central regulation of blood pressure has been questioned, since drugs such as clonidine stimulate both α 2-adrenoceptors and imidazoline-preferring receptors. The present work was undertaken to study the influence of α 2 D -adrenoceptors, encoded by the RG20 gene, on blood pressure in the rat. An antisense phosphodiester oligodeoxynucleotide, directed at nucleotides 4–21 of the RG20 gene, was injected in the right lateral cerebral ventricle, causing an increase in systolic blood pressure, both at 1 and 2 days after the injection, when compared to groups of control rats (injected with the sense oligodeoxynucleotide or a missense oligodeoxynucleotide or distilled water). Antisense oligodeoxynucleotides directed either at nucleotides 65–82 of the RG10 gene (encoding for α 2 C -adrenoceptors) or at nucleotides 26–43 of the RNG gene (encoding for α 2 B -adrenoceptors), failed to produce any change in blood pressure after being injected. We conclude that the α 2-adrenoceptor encoded by the RG20 gene may play a role in blood pressure regulation in the rat.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
